# Tiger Shi - Research Portfolio > Online research journal documenting published & unpublished works. ## Posts - [Hello world!](https://tigershi-research.org/hello-world/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] ## Pages - [Poetry Translations - Miscellaneous](https://tigershi-research.org/poetry_misc/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Poetry Translations - Book of Paths](https://tigershi-research.org/poetry_book-of-paths/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Poetry Translations - Book of Songs](https://tigershi-research.org/poetry_book-of-songs/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Publications](https://tigershi-research.org/publications/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Poetry Translations - 300 Tang Poems](https://tigershi-research.org/poetry_tang-poetry-300/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Patents](https://tigershi-research.org/patents/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Home](https://tigershi-research.org/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] - [Contact](https://tigershi-research.org/contact/): Home Publications Published Research Articles N/A Hypoxia-Induced Drug-Resistant Bias 3D Cancer Spheroid Drug Screens APL Bioengineering (2026), 10(1), 016113 Tiger H. Shi, Yu-Tang Huang, Hyunsu Jeon, Daniel Montes-Pinzon, Peter Mu-Hsin Chang, Nai-Jung Chiang, John Alex Sinclair, Angela Taglione, Donny Hanjaya-Putra, Yichun Wang, Chi-Ying F. Huang, and Hsueh-Chia Chang Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve IC50 (dosage for 50% inhibition) even for unreasonably high applied drug concentrations (up to 1000× 2D IC50). By mapping […] ## Optional - [Agent (MCP protocol)](websites-agents.hostinger.com/tigershi-research.org/mcp) [comment]: # (Generated by Hostinger Tools Plugin)